Impact of HAE
The burden of HAE may persist beyond the attack
You may already know the signs and symptoms of HAE, but assessing its full impact on your patients may help inform treatment goals and planning.
Even after the physical symptoms of an attack subside, a patient may still be affected by HAE. For many, the anticipation of an HAE attack dictates what patients can or cannot do.1
Due to the unpredictable nature of the disease, some patients reported high levels of distress and anxiety in everyday life. These feelings are attributed to:1,2
- Interrupted social life
- Disrupted educational aspirations
- Anxiety of future attacks
- Fear of passing HAE to their children
Good to know
In a European study,* 38% and 14% of patients with HAE had clinically meaningful anxiety and depression, respectively, vs global rates of 3.6% and 4.4% from the World Health Organization (indirect comparison).3,4
In addition to absences and lost productivity, patients reported that HAE has hindered their career or education by:5,6
- Impacting educational choices†
- Preventing them from applying to certain jobs*
- Causing them to resign or switch positions within a company†
Furthermore, the impact of HAE goes beyond those affected with HAE. Caregivers, who are typically family members, require time off work to care for their affected relative. Caregiver absenteeism was reported in 52% of attacks and comparable with that of the affected relative.2
Because of this, patients are often reluctant to:1,2
- Travel and go away on holiday
- Participate in certain hobbies
- Play sports and other physical activities
- Go to social events
This goes beyond cancelling plans – some patients would not consider planning these activities in the first place.1
Adolescents have reported that having HAE impairs their participation in school and peer-group activities, such as sport.1,2
*Based on quantitative survey responses (n=186) in the 2011 Hereditary Angioedema Burden of Illness Study in Europe.3,6
†Based on the Work Productivity and Activity Impairment-General Health questionnaire (n=457), distributed in the United States from November 2007 to January 2008.5
Sarah - Impact of HAE
See how HAE can affect all aspects of daily life and how patients can live in fear of the next attack
Sarah - Positive impact of changing treatment
See how a change in treatment can have a positive impact on people living with HAE
You may find that adjusting your lifestyle, especially during stressful times, can help you manage the impact of HAE, including:
- Sticking to a set daily routine
- Eating a healthy diet
- Getting enough sleep
- Exercising regularly
- Avoiding triggers
Hear from patients with HAE:
Martin speaks about the impact HAE has on him and his family
Andreea speaks about how HAE affects her work and how she prevents attacks
- Bygum A, et al. Acta Derm Venereol 2015;95(6):706–10.
- Longhurst H, et al. Clin Rev Allerg Immunol 2016;51(2):230–9.
- Caballero T, et al. Allergy Asthma Proc 2014;35(1):47–53.
- World Health Organization. Geneva, Switzerland: WHO Document Production Services; 2017.
- Lumry W, et al. Allergy Asthma Proc 2010;31(5):407–14.
- Aygören-Pürsün E, et al. Orphanet J Rare Dis 2014;9:99.